Edwards' Analytical is proud to announce we are expanding our range of analytical capabilities with the addition of Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) to our already comprehensive range of equipment. This new addition joins the already vast range of equipment that Edwards' Analytical possesses - increasing further the services we are able to offer to our valued clients.
Analysis with ICP-MS is amongst the most powerful and versatile analytical techniques available. It has fast become a highly desired approach used within the scientific and engineering industries due to its advantages over other approaches, including an expansive range of applications and sensitivity. With recent and impending changes in legislation for the testing of elemental impurities in many products, Edwards' Analytical can help ensure your company remains compliant through our skilled application of ICP-MS.
ICP-MS is capable of detecting the majority of elements on the periodic table, from an atomic mass of 7 through to 250. With a wide and dynamic range of concentrations encompassing parts per trillion to parts per million, ICP-MS has a large and varied scope of applications in many industries including; pharmaceuticals, nutraceuticals, biotechnology, food and beverages, forensics, environmental health, toxicology, toy manufacturing, metallurgy and mining and many others.
Elemental analysis performed using ICP-MS has many advantages over other well established, effective spectrometric techniques. Not only does ICP-MS have excellent detection limits, it is a multi-element technique capable of detecting and quantifying all elements present in a solution. Other techniques such as Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) will provide analysis of a more limited range of elements and are restricted to only being able to analyse between 1 to 10 and 1-60 elements per determination respectively. ICP-MS consistently provides superbly precise and accurate results.
The use of ICP-MS has become increasingly relevant recently due to legislative additions and amendments being implemented in Britain and the EU regarding chemical element testing in certain products. United States Pharmacopeia (USP) 231 is being replaced with USP’s 232 and 233. These two new General Chapters focus on heavy metal impurities in drugs, drug products and excipients, dietary supplements and ingredients, and the analysis methods required to test for these impurities – with ICP-MS and ICP-OES being favoured instead of the current dependence of the somewhat outdated and less accurate AAS.
More elemental impurities will now have to be tested - with the range including arsenic, cadmium, lead, mercury, chromium, copper, iridium, manganese, molybdenum, nickel, osmium, palladium, platinum, rhodium, ruthenium and vanadium. The new legislation was due to come into force on May of this year but has now been deferred until May 1st, 2014. This extra time allows pharmaceutical companies the opportunity to consult with our experts with a view to change their analytical methodology in line with the new legislation.
Furthermore, the recent change in July 2013 in the Toy Safety Directive EN71 Part 3 has introduced the need for a larger range of heavy metals to be tested in any article likely to be in contact with a child, including toys, accessories and jewellery. Edwards' Analytical are able to meet the significant challenges presented with this change of legislation, specifically with helping our clients meet the stringent criteria as seen with hexavalent chromium. When used in combination with High-Performance Liquid Chromatography (HPLC), ICP-MS can provide speciation of elements such as chrome VI reducing the risk of non-compliance.
The addition of the new ICP-MS to Edwards’ analytical portfolio increases our range of services and reinforces our promise to clients to always invest in the most innovative technologies available.
For further information or to discuss your testing needs please feel free to contact us.